[1]银建中,程绍杰,贾凌云,等.搅拌式反应器内固-液两相悬浮特性的CFD模拟[J].应用科技,2009,36(11):11-16.[doi:10.3969/j.issn.1009-671X.2009.11.003]
 YIN Jian-Zhong,CHENG Shao-Jie,JIA Ling-Yun,et al.CFD simulation of solid-liquid suspension characteristics in stirred tank reactor[J].yykj,2009,36(11):11-16.[doi:10.3969/j.issn.1009-671X.2009.11.003]
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搅拌式反应器内固-液两相悬浮特性的CFD模拟
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《应用科技》[ISSN:1009-671X/CN:23-1191/U]

卷:
第36卷
期数:
2009年11期
页码:
11-16
栏目:
材料与化学
出版日期:
2009-11-25

文章信息/Info

Title:
CFD simulation of solid-liquid suspension characteristics in stirred tank reactor
文章编号:
1009- 671X(2009)11- 0011- 06
作者:
银建中程绍杰贾凌云银建伟
(1.大连理工大学 化工学院,辽宁 大连 116012; 2.大连理工大学 环境与生命学院,辽宁 大连 116024; 3.内蒙古包钢稀土高科技股份有限公司 基建设备部,内蒙古 包头 014030)
Author(s):
YIN Jian-ZhongCHENG Shao-JieJIA Ling-YunYin Jian-Wei
(1. School of Chemical Engineering,Dalian University of Technology,Dalian 116012,China; 2. School of Environmental and Biological Science and Technology,Dalian University of Technology,Dalian 116024,China; 3. Department of Basic Construction & Equipments,Inner Mongolia Baotou Steel Rare-Earth Hi-Tech Co.,Ltd,Baotou 014030,China)
关键词:
搅拌式反应器计算流体力学数值模拟琼脂糖凝胶活化反应
Keywords:
stirred tank reactor computational fluid dynamics numerical simulation sepharose activating reaction artificial neural networks
分类号:
TQ027.3
DOI:
10.3969/j.issn.1009-671X.2009.11.003
文献标志码:
A
摘要:
制备血液净化材料蛋白A免疫吸附柱过程中,搅拌式生物反应器的优化设计与放大技术是工业开发的重要环节.该文采用标准κ-ε湍流模型、多重参考系法,模拟搅拌式反应器内琼脂糖凝胶溶液加入固体催化剂后,形成的固-液两相体系的混合和悬浮特性.分别对DT、PBTD45、PBTU45搅拌桨的固相悬浮性能进行了研究,预测了完全离底悬浮的临界转速,并与Zwietering公式进行了比较.通过数值模拟,为反应器的优化设计提供了参考依据.
Abstract:
In the preparation of the blood purification material protein A immunoadsorption, the optimization design and scale-up of the stirred tank bioreactor are the key links of the industrial process. In this paper, standard κ-ε turbulence model and multi-reference frame method are applied to simulate the mixing and suspending characteristics of solid-liquid when adding solid catalyst to sepharose solution in the stirred tank reactor. By the researches on the solid phase suspended performance of three types of impellers, which are DT, PBTD45 and PBTU45, just-suspended impeller speeds are predicted, and the results are compared with the Zwietering correlation. Through the computational fluid dynamics simulations, the reference guidance is provided to optimize bioreactor for preparing the blood purification material.

参考文献/References:

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[3]银建中,程绍杰,贾凌云,等.搅拌式反应器的模拟与优化设计[J].化工装备技术,2009,30(4):1-7.
[4]程绍杰.搅拌式生物反应器的模拟、优化设计与放大研究[D].大连:大连理工大学,2009.
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备注/Memo

备注/Memo:
基金项目:863计划资助项目(2007AA02Z230).
作者简介:银建中(1964-),男,副教授,博士,主要研究方向:绿色过程技术与装备,E-mail:jzyin@dlut.edu.cn.
更新日期/Last Update: 2009-12-25